Sarcoplasmic reticulum in heart failure: central player or bystander?
نویسندگان
چکیده
Ronald M. Phillips , Prakash Narayan , Ana M. Gomez , Keith Dilly , Larry R. Jones , ́ W. Jonathan Lederer , Ruth A. Altschuld a,) a Department of Medical Biochemistry, Ohio State UniÕersity Medical Center, 333 Hamilton Hall, 1645 Neil AÕenue, Columbus, OH 43210-1218, USA b Departments of Molecular Biology and Biophysics and Physiology, UniÕersity of Maryland School of Medicine, Baltimore, MD 21201, USA c Krannert Institute of Cardiology and Department of Medicine, Indiana UniÕersity School of Medicine, Indianapolis, IN 46202, USA
منابع مشابه
Phospholamban phosphorylation by CaMKII under pathophysiological conditions.
Sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA2a) transports Ca2+ into the SR, decreasing the cytosolic Ca2+ during relaxation and increasing the SR Ca2+ available for contraction. SERCA2a activity is regulated by phosphorylation of another SR protein: Phospholamban (PLN). Dephosphorylated PLN inhibits SERCA2a. Phosphorylation of PLN by either cAMP or cGMP-dependent protein kinase at Ser16 or t...
متن کاملSarcoplasmic Reticulum Ca and Heart Failure Roles of Diastolic Leak and Ca Transport
Heart failure (HF) is a leading cause of death and enormous effort has focused at understanding the molecular and cellular mechanisms of the decreased cardiac contractility. While changes of other components contribute, it is generally agreed that much of the contractile deficit is due to reduced myocyte Ca transients.1,2 Alterations in Ca current (ICa) and action potential characteristics are ...
متن کاملCardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.
Ca(2+) is a central player in the excitation-contraction coupling of cardiac myocytes, the process that enables the heart to contract and relax. Mishandling of Ca(2+) is a central cause of both contractile dysfunction and arrhythmias in pathophysiological conditions such as heart failure (HF). Upon electrical excitation, Ca(2+) enters the myocytes via voltage-gated Ca(2+) channels and induces f...
متن کاملDefective glycosylation of calsequestrin in heart failure.
OBJECTIVE Levels of Ca2+ regulatory proteins have been extensively analyzed in cardiomyopathies as possible indices of change in sarcoplasmic reticulum (SR) structure and function. Measures of calsequestrin (CSQ), however, a critical protein component of the Ca2+ release complex in junctional sarcoplasmic reticulum, have provided little or no evidence of underlying dysfunction. We previously re...
متن کاملSingle channel recordings from human cardiac sarcoplasmic reticulum.
Native membrane vesicles of human cardiac sarcoplasmic reticulum have been fused with artificial lipid bilayers to obtain recordings of single chloride and calcium release channels. Tissue was obtained from the explanted hearts of patients with end-stage cardiac failure undergoing heart transplantation. Although previous studies of calcium uptake and release have shown that the function of the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cardiovascular research
دوره 37 2 شماره
صفحات -
تاریخ انتشار 1998